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Fields Changed

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Field Before After
Trial End Date January 31, 2025 December 31, 2026
Last Published January 05, 2024 06:32 PM September 01, 2025 02:30 PM
Primary Outcomes (End Points) Measured about 3 days after treatment - Depression score, happiness, flourishing - Self-reported prosociality, moral universalism, and social image concerns - Work-related outcomes (e.g. work satisfaction, intentions to leave job and to change career) - Schwartz values questions - First-stage outcomes with respect to their experience with Ayahuasca: Ego Dissolution Scale; Mystical Experience Questionnaire; Meaningfulness of Experience - Trip characteristics (e.g. what they tripped on, qualitative information on their experience) Measured about 6 weeks after treatment - Similar to the measures above, but some questions dropped and some added - Dropped: Schwartz values questions, first-stage ayahuasca experience measures (except meaningfulness of experience), trip characteristics - Added: dictator game, major decisions, what would you choose vs. what would make you happy, whether relationship mentioned at baseline has improved, work hours, measures of self-knowledge, and incentivized measure of social image concerns Measured 2, 4, and 6 weeks after treatment -Instagram posting behaviours [Update Jan 2024] Measured six months after treatment: - Depression, happiness, flourishing - Major decisions, social image self-report, relationship improvement, dictator game - Work-related outcomes: employment status, occupation, hours, income, etc. [likely for a separate, future paper with linked RAIS administrative data (there is a delay before we can link the RAIS data for the current year)] Measured about 3 days after treatment - Depression score, happiness, flourishing - Self-reported prosociality, moral universalism, and social image concerns - Work-related outcomes (e.g. work satisfaction, intentions to leave job and to change career) - Schwartz values questions - First-stage outcomes with respect to their experience with Ayahuasca: Ego Dissolution Scale; Mystical Experience Questionnaire; Meaningfulness of Experience - Trip characteristics (e.g. what they tripped on, qualitative information on their experience) Measured about 6 weeks after treatment - Similar to the measures above, but some questions dropped and some added - Dropped: Schwartz values questions, first-stage ayahuasca experience measures (except meaningfulness of experience), trip characteristics - Added: dictator game, major decisions, what would you choose vs. what would make you happy, whether relationship mentioned at baseline has improved, work hours, measures of self-knowledge, and incentivized measure of social image concerns Measured 2, 4, and 6 weeks after treatment -Instagram posting behaviours [Update Jan 2024] Measured six months after treatment: - Depression, happiness, flourishing - Major decisions, social image self-report, relationship improvement, dictator game - Work-related outcomes: employment status, occupation, hours, income, etc. [likely for a separate, future paper with linked RAIS administrative data (there is a delay before we can link the RAIS data for the current year)] [Update September 2025] Measured 2 years after treatment (likely for a separate paper on longer-run effects): - Depression, happiness, flourishing - Relationship improvement - Work-related outcomes: employment status, occupation, hours, income, etc. Note: we will not survey no-shows for this 2-year follow-up. We will just survey those that attended their assigned session (excluding one session in which, by accident, all attendees were treated).
Secondary Outcomes (End Points) Measured about 3 days after treatment - Self-awareness - Predicted happiness - Social image concerns with respect to revealing on social media about their experience with Ayahuasca - Dreams characteristics (e.g. whether dreamed, whether dreams were positive) - Self-reported competitiveness Measured about 6 weeks after treatment - Creativity - Whether dreamed - Religiosity and spirituality - Predicted study effects on depression - Overall health self-evaluation - Behavioural change self-report [Update Jan 2024] Measured six months after treatment: - Big-5 scale - Ayahuasca and other psychedelic/drug use (to test for whether first stage persists) - Overall health self-evaluation, health symptoms report (to capture possible negative side effects) - Credit, savings, debt - Behavioural change self-report Measured about 3 days after treatment - Self-awareness - Predicted happiness - Social image concerns with respect to revealing on social media about their experience with Ayahuasca - Dreams characteristics (e.g. whether dreamed, whether dreams were positive) - Self-reported competitiveness Measured about 6 weeks after treatment - Creativity - Whether dreamed - Religiosity and spirituality - Predicted study effects on depression - Overall health self-evaluation - Behavioural change self-report [Update Jan 2024] Measured six months after treatment: - Big-5 scale - Ayahuasca and other psychedelic/drug use (to test for whether first stage persists) - Overall health self-evaluation, health symptoms report (to capture possible negative side effects) - Credit, savings, debt - Behavioural change self-report [Update September 2025] Measured 2 years after treatment (likely for a separate paper on longer-run effects): - Ayahuasca and other psychedelic/drug use (to test for whether first stage persists) - Overall health self-evaluation, health symptoms report (to capture possible negative side effects) - Savings - Behavioural change self-report - Meaningfulness of their ayahuasca experience
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