Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study

Last registered on January 16, 2024

Pre-Trial

Trial Information

General Information

Title
Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study
RCT ID
AEARCTR-0012767
Initial registration date
December 31, 2023

Initial registration date is when the trial was registered.

It corresponds to when the registration was submitted to the Registry to be reviewed for publication.

First published
January 02, 2024, 11:02 AM EST

First published corresponds to when the trial was first made public on the Registry after being reviewed.

Last updated
January 16, 2024, 12:41 AM EST

Last updated is the most recent time when changes to the trial's registration were published.

Locations

Region

Primary Investigator

Affiliation
Foundation University Islamabad

Other Primary Investigator(s)

PI Affiliation
Foundation University Islamabad
PI Affiliation
Foundation University Islamabad
PI Affiliation
Foundation University Islamabad

Additional Trial Information

Status
Completed
Start date
2023-07-01
End date
2024-01-15
Secondary IDs
Prior work
This trial does not extend or rely on any prior RCTs.
Abstract
Hallucinations can occur in the absence of sensory stimulation and manifest in a range of sensory modalities, producing vivid experiences of nonexistent occurrences. Experiments in cognitive and experimental psychology have made good use of the idea that associative learning events might trigger conditioning-induced hallucinations. Hallucinations may have an impact on memory. Semantic memory can be changed by hallucinations. Although almost all of human behavior is based on semantic memory, which encompasses all learned information about the outside world, its neurological underpinnings are still unclear. These convergences allow for new representations of perceptual experience that are increasingly abstract and support a range of conceptual activities such as language, social cognition, object recognition, and the amazing ability of humans to remember the past and imagine the future. We first conducted a trial without audio conditioning to ascertain users' cognitive functioning when exposed to generated hallucinations. The results showed that a person's memory may be impacted by particular situations. Subsequently, we designed an interactive scenario with the goal of eliciting mild to moderate negative auditory-visual hallucinations conditioned with positive audio and positive to moderate positive visual hallucinations conditioned with negative audio, followed by a combination of the two. In both visually produced and visually induced hallucinations conditioned by the audio, participants acted out the scenario. Higher degrees of absorption were observed by those who rehearsed the hallucinations conditioned with audio, and this in turn increased the intensity of their cognitive response to the event. Using an advanced program called Psychopy, the individuals' cognitive states were evaluated through the use of a Semantic Memory Scale and PANSS to measure both positive and negative symptoms. Following their exposure to conditionally triggered hallucinations, there was a notable impact on the subjects' semantic memory.
External Link(s)

Registration Citation

Citation
Ghafoor, Adnan et al. 2024. "Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study." AEA RCT Registry. January 16. https://doi.org/10.1257/rct.12767-2.0
Experimental Details

Interventions

Intervention(s)
To explore effect of conditioning evoked hallucinations on memory of healthy individuals
Intervention Start Date
2023-07-01
Intervention End Date
2024-01-15

Primary Outcomes

Primary Outcomes (end points)
The significance of this experimental study is embedded in its research design. We are using a completely different approach to assess cognitive change. The cross-sectional designs, while potentially well-suited for large samples, are often underpowered, overgeneralized, and ill-approximated to the statistical assumptions implied by general linear methods. For these reasons, we are experimenting with time-series techniques to explicitly investigate the time-dependent variation that can be observed within individual subjects. We are going to assess cognitive changes of induced hallucinations both visual and auditory with different pairings between them over a very short period of time. We are going to find a direct relationship of hallucinations on the cognitive functioning especially on memory of human beings. This study will increase people’s interests towards temporal and time-series studies.
Primary Outcomes (explanation)
to develop interest in research

Secondary Outcomes

Secondary Outcomes (end points)
To develop interest in Research by promoting Experimental studies
Secondary Outcomes (explanation)
To develop interest in Research by promoting Experimental studies

Experimental Design

Experimental Design
This was a temporal, randomized, controlled trial with a block design that was double blinded. After presenting each stimulus, such as a positive video, negative video, positive audio, and negative video at T0, memory was first evaluated using the Semantic Memory Scale in conjunction with the PANNS Scale to measure Positive and Negative symptoms. Next, Positive Visual Hallucination conditioned with Positive Audio was induced, and evaluation was repeated at T1. Semantic memory was evaluated and positive visual hallucinations conditioned with the negative audio were produced during the T2 phase. To evaluate the semantic memory, negative visual hallucinations conditioned with negative audio were created in the T3 phase. In order to evaluate the participants' semantic memory along with positive and negative symptoms, negative hallucinations conditioned with positive audio were created in the final stage T4.
Experimental Design Details
This was a temporal, randomized, controlled trial with a block design that was double blinded. After presenting each stimulus, such as a positive video, negative video, positive audio, and negative video at T0, memory was first evaluated using the Semantic Memory Scale in conjunction with the PANNS Scale to measure Positive and Negative symptoms. Next, Positive Visual Hallucination conditioned with Positive Audio was induced, and evaluation was repeated at T1. Semantic memory was evaluated and positive visual hallucinations conditioned with the negative audio were produced during the T2 phase. To evaluate the semantic memory, negative visual hallucinations conditioned with negative audio were created in the T3 phase. In order to evaluate the participants' semantic memory along with positive and negative symptoms, negative hallucinations conditioned with positive audio were created in the final stage T4.
Randomization Method
Randomized done using PsychoPy.
Randomization Unit
30 individuals
Was the treatment clustered?
No

Experiment Characteristics

Sample size: planned number of clusters
30 university students
Sample size: planned number of observations
30
Sample size (or number of clusters) by treatment arms
30 students for experiment
Minimum detectable effect size for main outcomes (accounting for sample design and clustering)
Supporting Documents and Materials

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IRB

Institutional Review Boards (IRBs)

IRB Name
IRB Approval Date
IRB Approval Number

Post-Trial

Post Trial Information

Study Withdrawal

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Intervention

Is the intervention completed?
Yes
Intervention Completion Date
January 15, 2024, 12:00 +00:00
Data Collection Complete
Yes
Data Collection Completion Date
January 04, 2024, 12:00 +00:00
Final Sample Size: Number of Clusters (Unit of Randomization)
30 Students from Foundation University
Was attrition correlated with treatment status?
Yes
Final Sample Size: Total Number of Observations
30 individuals
Final Sample Size (or Number of Clusters) by Treatment Arms
30 individuals
Data Publication

Data Publication

Is public data available?
No

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Program Files

Program Files
No
Reports, Papers & Other Materials

Relevant Paper(s)

Reports & Other Materials

Description
Adnan, Rafay and Moeez. 2024 "Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study". AEA RCT Registry. January 16. 2024.
Citation
Ghafoor, Adnan et al. 2024. "Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study." AEA RCT Registry. January 16. 2024. "Registration Entry Title: Adnan, Rafay and Moeez. 2024 "Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study". AEA RCT Registry. January 16. 2024.." AEA RCT Registry. January 16 https://doi.org/10.1257/rct.12767-2.0
File
RESEARCH PROJECT.pdf

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Uploaded At: January 16, 2024