Evaluating the Impact of a Comprehensive School Health Program in Zambia

Last registered on April 15, 2026

Pre-Trial

Trial Information

General Information

Title
Evaluating the Impact of a Comprehensive School Health Program in Zambia
RCT ID
AEARCTR-0013890
Initial registration date
July 16, 2024

Initial registration date is when the trial was registered.

It corresponds to when the registration was submitted to the Registry to be reviewed for publication.

First published
July 17, 2024, 2:16 PM EDT

First published corresponds to when the trial was first made public on the Registry after being reviewed.

Last updated
April 15, 2026, 12:42 PM EDT

Last updated is the most recent time when changes to the trial's registration were published.

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Primary Investigator

Affiliation
LSE

Other Primary Investigator(s)

PI Affiliation
University of Virginia
PI Affiliation
Boston University and National Health Research Authority, Zambia
PI Affiliation
London School of Economics and Political Science
PI Affiliation
University of Notre Dame
PI Affiliation
London School of Economics and Political Science
PI Affiliation
University of Zambia

Additional Trial Information

Status
On going
Start date
2024-02-27
End date
2027-06-30
Secondary IDs
Prior work
This trial does not extend or rely on any prior RCTs.
Abstract
While much attention has been dedicated to the health and well-being of children under 5, the needs of older children have been historically overlooked. However, children between 5- and 14-years face health-related challenges higher than previously realized, during a period of life critical for physical, psychological, cognitive and social development. In Zambia, the context for this study, the prevalence of malaria is highest in children aged 5-17, with 40% of children testing positive in endemic areas; a study based in Lusaka, the capital also reported high levels of morbidity in primary school children, with 35% reporting febrile symptoms in the past two weeks, 66% reporting cough, 25% reporting diarrhea, and 32% having worms in their stool. Many of these problems are caused or compounded by inadequate access to prevention and treatment for school-age children. For example, they are less likely to sleep under a bednet than younger children. When ill, school-age children are less likely than other age groups to seek treatment, and when they do, less likely to seek care from formal providers. In Zambia, delayed treatment is often due to the high opportunity costs associated with long waiting times in over-crowded facilities, where children over 5 are no longer prioritized over adults. Long waiting times to access care are particularly acute when government health services are free, as in Zambia. In turn, health-related issues have a negative impact on education outcomes. They are a major cause of the 20-25% absenteeism rate observed amongst school children in Zambia, have been shown to lead to lower cognitive abilities, which, together with absenteeism, increases the likelihood of dropout and early marriage for girls.

In this study, we evaluate a programme which leverages the susbtantial expansion of primary school enrollment in Zambia and uses schools as a platform to improve access to preventive and curative healthcare services for children above five. Since 2015, our partner NGO Healthy Learners has partnered with the Zambian Government to develop a comprehensive and scalable school health program (SHP), making schools an entry point into the healthcare system. The SHP model consists of 4 key features: 1) building capacity by training teachers to become community health workers and building and equipping a school health room; 2) diagnosing and treating sick learners in school health rooms with the help of the ThinkMD clinical decision support system, or referring learners to the local health centre with a fast-track form; 3) proactive monitoring of absent and sick learners (e.g., following up after health centre referrals, a "buddy" system to check up on absent learners); 4) prevention through school health education (delivered by trained teachers) and supply of preventive care in partnership with local health facilities (e.g., vitamin A, deworming, etc.)

While many SHPs in low-income settings only focus on the delivery of some preventive services (eg. deworming, school meals, health talks), the comprehensive model creates a platform that improves access to and delivery of both preventive and curative services. Unlike a school nurse program, which is financially unsustainable, impractical in settings with health staff shortages, and places the onus of providing health services on one individual health worker, this model is integrated into the structures of the Ministry of Education and leverages resources from the entire school community to become involved in supporting the health of students.

We evaluate the impact of the SHP in a cluster-randomised controlled trial conducted in 225 schools, which we will randomly assign to one of three treatment groups: 1) a standard of care control group; 2) the School Health Programme; 3) only the mass drug administration (e.g. deworming) component of the SHP, which will enable us to benchmark the cost-effectiveness of the SHP against mass administration of deworming drugs. The proposed research will answer five main questions:
(1) What factors affect the implementation of the comprehensive SHP and how costly is it?
(2) What is the impact of the programme on health, health-seeking and education outcomes?
(3) What is the added value of such a comprehensive SHP, compared to (i) reliable (ii) or imperfect delivery of a limited range of default school health activities (e.g. deworming)?
(4) What are the indirect effects of the SHP on teachers, schools, health-workers and clinics?
(5) What are the potential implications of the programme for long-term human capital accumulation?
External Link(s)

Registration Citation

Citation
Avitabile, Andrew et al. 2026. "Evaluating the Impact of a Comprehensive School Health Program in Zambia." AEA RCT Registry. April 15. https://doi.org/10.1257/rct.13890-2.0
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Experimental Details

Interventions

Intervention(s)
Since 2015, our partner NGO Healthy Learners has partnered with the Zambian Government to develop a comprehensive and scalable school health program (SHP), making schools an entry point into the healthcare system. The SHP model consists of 4 key features: 1) building capacity by training teachers to become community health workers and building and equipping a school health room; 2) diagnosing and treating sick learners in school health rooms with the help of the ThinkMD clinical decision support system, or referring learners to the local health centre with a fast-track form; 3) proactive monitoring of absent and sick learners (e.g., following up after health centre referrals, a "buddy" system to check up on absent learners); 4) prevention through school health education (delivered by trained teachers) and supply of preventive care in partnership with local health facilities (e.g., vitamin A, deworming, etc.)
Intervention Start Date
2024-09-02
Intervention End Date
2026-11-27

Primary Outcomes

Primary Outcomes (end points)
1. Any healthcare utilisation
2. Healthcare utilisation conditional on need
3. Attendance rate
Primary Outcomes (explanation)
1. Any healthcare utilisation
The proportion of learners who sought formal care (any government health centre or hospital, or the school health room). Equals one if reported at least once during the health diary observation period.
[Time Frame: 8-week period across term 1 and term 2 2026]

2. Healthcare utilisation conditional on need
Conditional measure of healthcare use, restricted to the sample of children who have experienced at least one ‘serious’ illness episode, defined as one which requires medical attention according to WHO c-IMCI and IMAI guidelines. The outcome is the ratio of the number of illness episodes during which a child seeks medical care over the total number of serious illness episodes experienced by a child, for all children who have experienced at least one serious illness episode over the period.
[Time Frame: Eight week diary observation period]

3. Attendance rate
We assess the program’s effect on school attendance using data collected through repeated, unannounced spot checks at each school. Our primary attendance measure will be based on the sample of children enrolled in the study at baseline and confirmed to still be enrolled in their original school at the time of the visit. In this sample, the attendance rate, measured at each attendance spot check, will be the proportion of those children confirmed present in class on the day of the visit.
[Time Frame: 24 months after intervention start]

Secondary Outcomes

Secondary Outcomes (end points)
4. Index of health knowledge
5. Proportion of children with moderate or severe anaemia
6. Proportion of children who are underweight
7. Proportion of children who are overweight
8. Proportion of children with diarrhoea
9. Proportion of children testing positive for malaria
10. Menstrual hygiene management
11. Combined measure of attendance and retention
12. Attendance rate including learners transfered to other study schools
13. Cross-section attendance
14. Learning
15. Students' working memory and attention
Secondary Outcomes (explanation)
4. Index of health knowledge
A standardized index score derived from a maximum of 10 questions covering diarrhea, malaria prevention, hygiene, and questions aligned with the program curriculum.
[Time Frame: At point of endline]

5. Proportion of children with moderate or severe anaemia
Haemoglobin concentration measured using a HemoCue photometer in the sample of children taking part in the health diaries (testing will occur at the end of the period). Anemia severity categories will be based on the WHO classification which depends on the age and sex of the child.
[Time Frame: Half of the sample captured in term 1 2026 and half in term 2 2026]

6. Proportion of children who are underweight
Using height and weight measured for all learners surveyed at endline, we will construct weight-for-age z-scores and determine the proportion of children who are underweight.
[Time Frame: Endline]

7. Proportion of children who are overweight
Using height and weight measured for all learners surveyed at endline, we will construct weight-for-age z-scores and determine the proportion of children who are overweight.
[Time Frame: Endline]

8. Proportion of children with diarrhoea
Incidence of diarrhoea - carer report of the child experiencing three or more loose or watery stools.
[Time Frame: Over the eight week follow-up period across term 1 and 2 in 2026]

9. Proportion of children testing positive for malaria
Testing for the presence of P. falciparum. The tests are performed using a rapid diagnostic test (RDT) on the sample of children taking part in the health diaries (testing will occur at the end of the period).
[Time Frame: End of health diaries in term 1 and term 2 2026]

10. Menstrual hygiene management
We examine the impact of the programme across three domains: knowledge, practices, and stigma. For each domain, we draw on questions developed and validated in prior studies (Austrian, Kangwana et al. 2021, Kansiime, Hytti et al. 2022, Hennegan, Hasan et al. 2024, Macours, Vera et al. 2024). For each sub-scale, we will construct a summary index using principal component analysis, standardized as a z-score using the mean and standard deviation of the control group for ease of interpretation of the results. In analysis, we will look at the impact of the programme on each of these domains separately, as well as combined.
[Time Frame: Endline]

11. Combined measure of attendance and retention
Proportion of children confirmed present in class on the day of the visit, out of the total number of children enrolled at the school at baseline and still alive. In this measure, we effectively treat children who may have transferred to another study school as ‘absent’, dropped out, or temporarily relocated.
[Time Frame: Five random spot checks across 18 months]

12. Attendance rate including learners transfered to other study schools
Proportion of children confirmed present in class on the day of the visit either in their original school or in another school to which they have transferred if that school is one of the study schools, out of the total number of children enrolled at baseline and still alive. Following an Intention-to-Treat principle, we will analyse participants based on the arm they were originally assigned to, even if they moved to a different study arm school.
[Time Frame: Five unannounced spot checks across 18 months]

13. Cross-section attendance
Additional measure of attendance, focusing on students in grades 1, 3, 5, and 7 at the time of the spot check. This register-based measure is defined as the proportion of children on the register who are present on the day of the spot check. The denominator will be defined by the list of children in each of the four grades who are confirmed by a school staff member as enrolled in the school on the day of the visit.
[Time Frame: Four randomised spot checks conducted across 12 months]

14. Learning
Learning is measured using individually administered numeracy, literacy, and science examinations. Items for these exams are aligned with the Zambian Ministry of Education national curriculum for Grades 1 through 7. Each assessment will be conducted one-on-one by trained enumerators at the start of the learners’ interviews. Items are developed by local curriculum experts and calibrated through pilot testing to ensure grade-appropriate difficulty. We will also borrow items from international test banks (e.g., TIMSS, EGRA, EGMA). Finally, we will classify items using Bloom’s taxonomy to test for differences in effects across higher- and lower-order thinking skills. In analysis, we will look at each domain separately as well as a combined score.
[Time Frame: Endline]

15. Students' working memory and attention
We measure students’ working memory and attention using the Digit Span task, a widely used short-term memory and working memory assessment. Enumerators orally present a sequence of digits at a rate of one per second, and students are asked to repeat the digits in the same order (Digit Span Forward) and then in reverse order (Digit Span Backward). The task measures students’ auditory attention, concentration, and working memory capacity, which are foundational components of general cognitive functioning and predictive of academic achievement. Scores are recorded as the total number of correct sequences reproduced, following standard administration and scoring procedures. Additional cognitive and non-cognitive measures may be added depending upon validation during piloting. These include Raven's Progressive Matrices, Interactive Stroop Tests, and pattern recognition tasks.
[Time Frame: Endline]

Experimental Design

Experimental Design
We will assess the impact of the SHP in a parallel-arm, cluster-randomised controlled trial (cRCT) in 225 schools (clusters), with a 1:1.25:1.5 allocation ratio of clusters to delivery of (i) the usual school health activities (the control group – 75 schools), (ii) the SHP intervention (90 schools), and (iii) mass drug administration. The trial will be conducted in primary schools (including children from Grade 1 to Grade 7, aged 7-14 years old) in six districts in the Copperbelt (Luanshya, Chingola, Masaiti) and Luapula (Samfya, Mwense, Kawambwa) provinces, covering a range of urban, peri-urban, and rural areas, as well as varying levels of endemicity of infectious diseases (malaria and worms). Of the 286 government schools currently in these districts, Healthy Learners identified 250 that meet their eligibility criteria for programme implementation (sufficient staffing and reachable during the rainy season). Of those, we randomly selected 225 for the trial. To ensure a balanced sample with respect to geography and school environment, the randomization was stratified by district and school size.

In each school, we will collect data from (i) a random sample of 60 learners in Grade 1 (G1), G3 and G5 in 2024 who are present at the time of the baseline survey, whose parent/guardian will provide consent and who will assent to the study; (ii) a random sub-sample of 30 from sample (i) invited to take part in the symptom diary sub-study; (iii) a yearly sample of four classes (G1, G3, G5 and G7) comprising about 120-160 students in total, for the attendance study; (iv) a sample of one headteacher and up to 10 teachers present at baseline and who consent to the study; (v) a sample of 145 healthcare facilities serving the study schools and up to three health workers who staff these facilities.
Experimental Design Details
Not available
Randomization Method
Randomisation algorithm in STATA
Randomization Unit
School
Was the treatment clustered?
Yes

Experiment Characteristics

Sample size: planned number of clusters
225 schools
Sample size: planned number of observations
13,300 households; 13,300 learners; 225 school administrators; 1,700 teachers; 145 health facility administrators; 300 health workers
Sample size (or number of clusters) by treatment arms
90 schools in SHP arm; 75 schools in standard of care control group; 60 schools in mass drug administration arm
Minimum detectable effect size for main outcomes (accounting for sample design and clustering)
We computed power calculations and concluded that our study was well-powered for the two co-primary outcomes defined above. We use a significance level of 5% and estimate minimum detectable effect (MDE) sizes with 80% power. We report MDEs based on intention-to-treat effects. Unconditional use of health care. We expect the most direct effect of the school health programme to be an increase in the healthcare utilisation (HA1). In a pilot study carried out in October 2025, 31% of children surveyed sought care at least one. Assuming an intra-cluster correlation of 0.30 (higher than the one estimated during the pilot), we are powered to detect an increase of 10.5 percentage point in the probability of ever seeking care in the SHP arm relative to the control arm. Conditional use of needed health care. We expect the biggest and most direct effect of the school health programme to be an increase in the utilisation of health care when needed (HA1). This outcome is conditional on a child experiencing at least one serious illness episode over the observation period. Based on results obtained from a pilot study carried out in October 2025, we expect that about 50% (i.e., approximately 12) of the 24 children followed in each school will experience at least one illness episode illness episodes warranting medical assessment over the 8-week observation window (this proportion likely under-estimates the prevalence of morbidity episodes we will observe during the data collection, which will take place during the rainy season, whereas the pilot occurred in a lower-morbidity season), and that they will seek medical care on average 70% of the time. Assuming an intra-cluster correlation of 0.35 (higher than the one estimated during the pilot), we are powered to detect a difference of 11.9 percentage point in the probability of seeking care between the SHP arm and the control arm. Appendix Table 1 shows that the range of minimal detectable effect size between 8.5-13.9 points, depending on the assumptions made about (1) the intra-cluster correlation, (2) the proportion of children seriously ill and (3) the proportion of healthcare utilisation in the control group. These MDEs are within the range of effects documented in randomised evaluations of interventions aiming to increase utilisation of care in LMICs. Performance-based financing in Rwanda, Zimbabwe, and Cambodia have found increases in facility-based service use of 7 to 9 percentage points (Basinga, Gertler et al. 2011, Van de Poel, Flores et al. 2016), while demand-side interventions combining financial incentives with improved access have generated effects of 27 percentage points (Thornton 2008). Our intervention primarily reduces the physical distance to care for children and families in rural areas, one of the most consistently documented barriers to healthcare utilisation in sub-Saharan Africa. As such, it is closest to studies looking at demand-side interventions reducing opportunity cost and distance such as Thornton (2008), which has been shown to generate among the largest demand responses in the literature. A 10-12 percentage point MDE therefore represents a conservative benchmark: it lies above the effects found in studies relying on information provision or modest financial nudges alone, yet comfortably within the range achieved by access-enhancing interventions operating in similarly supply-constrained environments. School attendance. We expect the school health programme to increase attendance in school (HA2). Earlier management of illnesses, school-based deworming, health education, and support to menstruating girls all help prevent common causes of absenteeism, such as untreated infections and poor menstrual hygiene, while the peer-buddy system ensures that children return to school more quickly after illness and that school staff are more attuned to learner absenteeism. For this outcome, the unit of analysis is the child. As described in section 3.4.2, our primary measure of attendance will be measured using the panel sample. At baseline, the intra-cluster correlation (ICC) of attendance at the school level using the panel-based method was 0.039 (controlling for stratification-cell fixed effects). In our power calculations, we test for the minimum detectable effect between the six comparisons we plan to make across treatment arms (e.g., Full Healthy Learners treatment vs. control, Full Healthy Learners treatment vs. deworming, and deworming vs. control). We calculate the minimum detectable effect size for each comparison assuming a two-sided significance level of α = 0.05, a conservative ICC of 0.05, and 80 percent power, accounting for clustering at the school level. We assume 89 Healthy Learners treatment schools (reflecting one treatment school that dropped out after baseline), 60 deworming schools, and 75 pure control schools, with an average of 58 sampled learners per school. We conduct these calculations across baseline attendance rates of 0.5, 0.6, and 0.7. Attendance rates measured in the panel survey are expected to be lower than those from government measures based on school registers due to survey attrition and the requirement that students be observed and present across multiple survey rounds. The study is powered to detect effects on attendance of approximately 4 to 6 percentage points. The results of this can be found in Appendix Table 2. Minimum detectable effects range from roughly 5.0 to 6.3 percentage points, with smaller MDEs at higher baseline attendance rates. Across comparisons, minimum detectable effects are largest for Deworming versus Control arms and smallest for comparisons involving the Full HL Treatment, reflecting differences in the number of schools across arms.
IRB

Institutional Review Boards (IRBs)

IRB Name
ERES Converge
IRB Approval Date
2023-12-07
IRB Approval Number
2023-Oct-010
IRB Name
LSE Research Ethics Committee
IRB Approval Date
2023-10-12
IRB Approval Number
264865
IRB Name
National Health Research Authority
IRB Approval Date
2024-01-25
IRB Approval Number
NHREB001/25/01/2024
Analysis Plan

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