Willingness to Participate in Clinical Drug Trials

Last registered on July 16, 2024
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Pre-Trial

Trial Information

General Information

Title
Willingness to Participate in Clinical Drug Trials
RCT ID
AEARCTR-0013920
Initial registration date
July 12, 2024

Initial registration date is when the trial was registered.

It corresponds to when the registration was submitted to the Registry to be reviewed for publication.

First published
July 16, 2024, 3:33 PM EDT

First published corresponds to when the trial was first made public on the Registry after being reviewed.

Locations

Country
United States of America
Region

Primary Investigator

Name
Natalia Emanuel
Affiliation
Federal Reserve Bank of New York
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Other Primary Investigator(s)

PI Name
Alyssa Bilinski
PI Affiliation
Brown University
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Additional Trial Information

Status
In development
Start date
2024-07-12
End date
2024-11-01
Keywords
Health
Additional Keywords
Clinical Trials, Pregnancy, Ethics, IRB
JEL code(s)
I12, I18
Secondary IDs
Prior work
This trial does not extend or rely on any prior RCTs.
Abstract
We study the willingness of individuals to participate in clinical trials under various circumstances. We ask individuals to imagine a medical circumstance, a set of available treatments with a given evidence base, including a clinical drug trial that is testing a specific medication. We then ask respondents how they would choose to address the medical circumstance. We seek to understand which traits of the individual, their circumstance, and trial best predict willingness to enroll in a trial.
External Link(s)

Registration Citation

Citation
Bilinski, Alyssa and Natalia Emanuel. 2024. "Willingness to Participate in Clinical Drug Trials." AEA RCT Registry. July 16. https://doi.org/10.1257/rct.13920-1.0
Sponsors & Partners
Experimental Details

Interventions

Intervention(s)
Intervention (Hidden)
Some vignettes ask the participant to imagine that they are pregnant (in the case of some respondents who are assigned female at birth) or are counseling a pregnant loved one (in the case of the rest of the assigned-female-at-birth participants and all assigned-male-at-birth participants).
Intervention Start Date
2024-07-12
Intervention End Date
2024-11-01

Primary Outcomes

Primary Outcomes (end points)
Whether the respondent indicates willingness to participate in a clinical trial in this circumstance
Primary Outcomes (explanation)

Secondary Outcomes

Secondary Outcomes (end points)
Secondary Outcomes (explanation)

Experimental Design

Experimental Design
Our vignettes randomize the condition of the patient, whether the condition is preexisting or a new diagnosis, the existence of available medical treatments, and whether the clinical trial gives some participants one medication and some another or varies the dosage of a single medication. The order of the vignettes and of the answers is also randomized.
Experimental Design Details
If the respondent is assigned female at birth, the vignettes further randomize whether the respondent is asked to imagine they are 9 weeks pregnant, 20 weeks pregnant or not pregnant. For a portion of respondents who are assigned female at birth and for respondents who are assigned male at birth, some vignettes randomize whether the respondent is considering their own health or are counseling a loved one who is 9 or 20 weeks pregnant.
Randomization Method
Qualtrics randomization
Randomization Unit
Individual vignette
Was the treatment clustered?
Yes

Experiment Characteristics

Sample size: planned number of clusters
1200 individuals in the nationally representative sample; an additional 350 in the oversampled population.
Sample size: planned number of observations
1550 individuals, receiving an average of 2.5 vignettes each = 3,875 observations
Sample size (or number of clusters) by treatment arms
All individuals receive a mix of circumstances
Minimum detectable effect size for main outcomes (accounting for sample design and clustering)
Supporting Documents and Materials
IRB

Institutional Review Boards (IRBs)

IRB Name
Brown University Human Research Protection Program
IRB Approval Date
2024-07-10
IRB Approval Number
STUDY00000306
Analysis Plan

Post-Trial

Post Trial Information

Study Withdrawal

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Intervention

Is the intervention completed?
No
Data Collection Complete
Data Publication

Data Publication

Is public data available?
No

Program Files

Program Files
Reports, Papers & Other Materials

Relevant Paper(s)

Reports & Other Materials