Gender Differences in Suicide and Depression

Last registered on October 28, 2024

Pre-Trial

Trial Information

General Information

Title
Gender Differences in Suicide and Depression
RCT ID
AEARCTR-0014621
Initial registration date
October 21, 2024

Initial registration date is when the trial was registered.

It corresponds to when the registration was submitted to the Registry to be reviewed for publication.

First published
October 28, 2024, 12:55 PM EDT

First published corresponds to when the trial was first made public on the Registry after being reviewed.

Locations

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Primary Investigator

Affiliation

Other Primary Investigator(s)

PI Affiliation
University of Lausanne
PI Affiliation
Norwegian Institute of Public Health

Additional Trial Information

Status
In development
Start date
2024-10-22
End date
2025-10-31
Secondary IDs
Prior work
This trial does not extend or rely on any prior RCTs.
Abstract
Substantial gender disparities in depression and suicide rates are observed worldwide. While women are more frequently diagnosed with depression, men have a substantially higher rate of completed suicides. This project aims to investigate whether gender differences in the recognition of mental health issues and the likelihood of seeking help contribute to these patterns. The project consists of (1) an analysis of mental health diagnoses and suicide data using administrative records from Norway, and (2) an online experiment with a representative U.S. sample, aiming to identify whether mental health symptom recognition and willingness to seek help differ by gender.
External Link(s)

Registration Citation

Citation
Abrahamsson, Sara, Catalina Franco and Akshay Moorthy. 2024. "Gender Differences in Suicide and Depression." AEA RCT Registry. October 28. https://doi.org/10.1257/rct.14621-1.0
Experimental Details

Interventions

Intervention(s)
The study uses a within-subjects design wherein all participants are exposed to two treatment blocks. In each of these blocks, participants will be shown one or more hypothetical scenarios. A scenario involves a list of depression symptoms and the frequency of their occurrence. The study uses a within-subjects design wherein all participants are exposed to two treatment blocks. In each of these blocks, participants will be shown one or more hypothetical scenarios. A scenario consists of a list of depression symptoms and the frequency of their occurrence over the past two weeks. The displayed symptoms are chosen from the PHQ-9 questionnaire, which is a widely used (and often self-administered) instrument that screens for depressive disorders. The list of symptoms and frequencies are randomly chosen to meet certain thresholds which indicate different levels of depression severity.

After reviewing the hypothetical scenario, participants are asked to state their views on: (i) whether the symptoms indicate that the subject of the scenario suffers from depression (recognition), (ii) perceptions of depression severity, (iii) the likelihood of seeking help from different sources, and (iv) beliefs and attitudes regarding depression and mental health.
Intervention Start Date
2024-10-23
Intervention End Date
2024-10-31

Primary Outcomes

Primary Outcomes (end points)
The three primary outcomes are Recognize, Correct and Seek help. Recognize is a binary variable equal to 1 if the answer to Q1 is definitely yes or probably yes, and 0 otherwise. Correct is the outcome to assess whether participants assess the severity of depression correctly. It takes the value of 1 if the severity level is identified correctly and 0 otherwise. Seek help captures the willingness to seek help after seeing the list of symptoms and answering Q1 and Q2. We will use the responses to Q3 to generate an outcome variable which equals 1 if the response is somewhat likely or very likely for one or more of the options presented in Q3 and 0 otherwise.
Primary Outcomes (explanation)

Secondary Outcomes

Secondary Outcomes (end points)
The first set of secondary outcomes contained whether help would be sought from a mental health specialist or from non-specialists. The specialist variable will be equal to 1 if the response is somewhat likely or very likely in at least one of options 1-3 in Q3 and 0 otherwise. The non-specialist variable will be equal to 1 if the response is somewhat likely or very likely in at least one of options 4-6 in Q3 and 0 otherwise.

The second set of secondary outcomes we intend to capture three different factors that could underlie gender differences in recognizing depression and seeking help. We refer to these three factors as perceptions, psychic costs and norms.

To capture gender differences in perceptions we will generate binary outcomes from each of the answer options in Q4. Each of these variables would be equal to one if the response is somewhat or strongly agree and 0 otherwise. We will also generate an index summarizing the perceptions in a single variable.

To study psychic costs, we will use the Self and Other scenarios and create a binary variable equal to 1 if the scenario being evaluated corresponds to Other.

To study norms, we will survey responses to Q5.
Secondary Outcomes (explanation)

Experimental Design

Experimental Design
The experiment involves randomly choosing a list of depression symptoms and severity of symptoms from the PhQ-9 questionnaire to build a scenario that participants are prompted to assess. The two treatment blocks refer to who is the subject of the scenario (Self or Other). we choose symptoms (i.e., items form the PHQ-9 scale) and frequencies so that the combinations of symptoms and frequencies gives an overall score between 5 and 27.
Experimental Design Details
Not available
Randomization Method
All participants see scenarios in both Self and Other in randomized order. The list of symptoms and frequencies is randomly selected based on a pre-defined algorithm.
Randomization Unit
Individual - within subject.
Was the treatment clustered?
No

Experiment Characteristics

Sample size: planned number of clusters
Non-clustered design.
Sample size: planned number of observations
300 individuals who evaluate 4 scenarios.
Sample size (or number of clusters) by treatment arms
1200 observations from 300 individuals who evaluate 4 scenarios each.
Minimum detectable effect size for main outcomes (accounting for sample design and clustering)
Supporting Documents and Materials

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IRB

Institutional Review Boards (IRBs)

IRB Name
IRB at NHH Norwegian School of Economics
IRB Approval Date
2024-08-29
IRB Approval Number
NHH-IRB 79/24
Analysis Plan

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