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Trial Start Date
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Before
November 03, 2025
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After
November 16, 2025
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Last Published
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Before
October 13, 2025 09:57 AM
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After
March 06, 2026 07:04 AM
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Intervention Start Date
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Before
November 03, 2025
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After
December 01, 2025
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Primary Outcomes (End Points)
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Before
The primary outcomes of interest in this experiment are participants’ beliefs about vaccinations, the healthcare system, and health professionals.
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After
The primary outcomes capture participants’ beliefs and attitudes toward vaccination and public health institutions following exposure to the informational intervention. The main endpoints are summary indices constructed from post-treatment survey responses:
Trust in Vaccines Index
Trust in Healthcare System / Health Authorities Index
Vaccination Acceptance / Vaccination Intent
These outcomes measure the extent to which exposure to the informational message affects participants’ trust in vaccination, trust in medical institutions, and willingness to accept vaccination recommendations.
Each index will also be analyzed through its individual components as secondary specifications.
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Primary Outcomes (Explanation)
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Before
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After
Trust in Vaccines Index
This index captures participants' beliefs about the effectiveness, safety, and importance of vaccines. It is constructed using responses to the following four items measured on a 0–10 scale:
"Vaccines are effective at preventing pandemics and serious diseases."
"Vaccines are safe for human health."
"Vaccines are important for your own health."
"Vaccines are important for public health."
Trust in Healthcare System Index
This index measures trust in institutions responsible for health and medical care. It is constructed using 0–10 trust questions on:
"conventional medicine and surgery,"
"doctors and healthcare professionals,"
"public health authorities."
The main specification constructs a standardized index using principal component analysis (PCA) applied to these items. The first principal component will be used as the index. The PCA weights will be estimated using the full sample of post-treatment responses. We will also present results by the individual variables.
Vaccination Intent and Vaccination Status (Follow-up Survey)
The follow-up survey includes two measures related to vaccination behavior:
Willingness to vaccinate, capturing participants' stated intention to receive a vaccine.
Vaccination status, indicating whether the participant reports having received the vaccine.
Both variables are coded as as a binary indicator equal to one if the participant reports being more willing to vaccinate or having been vaccinated.
These outcomes allow us to examine whether exposure to the intervention affects both stated vaccination intentions and realized vaccination behavior at follow-up.
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Randomization Method
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Before
Each session will be randomly assigned to one treatment arm. All participants to a session will receive the same treatment.
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After
Each session will be randomly assigned to one treatment arm. All participants to a session will receive the same treatment. Within session, those participating to those sessions receiving the information treatment (either VR or Video) will be randomized into one of the 4 speakers: Male Scientist, Female Scientis, Male Influencer, Female Influencer.
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Planned Number of Clusters
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Before
The planned number of clusters corresponds to the total number of experimental sessions. Each session constitutes a cluster, with all participants in a session receiving the same treatment. In total, 65 sessions, each involving 30 students, are planned.
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After
Randomization occurs at the individual participant level. The study therefore does not involve clustered assignment. The planned sample is approximately 1,000 individual participants (clusters of size 1).
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Planned Number of Observations
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Before
The planned number of observations is 2,000, although we will try to collect more based on funding availability.
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After
The planned number of observations is 1,000, although we will try to collect more based on funding availability.
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Sample size (or number of clusters) by treatment arms
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Before
The planned sample size is of 2,000 students, although we will try to collect more based on funding availability.
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After
Approximately 333 participants in Control, 333 participants in Video, and 333 participants in VR. The primary treatment assignment is across three session-level arms: Control, Video, and VR. The presentation materials describe the treatment arms as VR, Video, or Control.
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Intervention (Hidden)
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Before
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After
The study evaluates how the medium of communication and the identity of the speaker affect how individuals receive and respond to a public health message about vaccination.
Participants are exposed to a standardized informational message describing the benefits and safety of vaccines and the role of immunization in preventing infectious diseases. The informational content of the message is identical across all treatment conditions. The message is delivered through videos featuring well-known Greek public figures whose professional identity varies across conditions.
Two types of speakers are featured:
Medical experts (scientists): practicing physicians and medical researchers affiliated with Greek medical institutions.
Social media influencers: Greek public communicators with a large online presence who regularly engage with young audiences.
In total, the study includes four speakers, varying by both professional identity and gender:
male scientist
female scientist
male influencer
female influencer
All speakers deliver the same scripted informational message.
The experiment varies two dimensions of the communication environment.
1. Medium of delivery
Participants are randomly assigned to one of three conditions:
Control: participants watch a short neutral video unrelated to vaccination.
Video: participants watch the informational message delivered by the speakers in a standard two-dimensional video on a computer screen.
Virtual Reality (VR): participants experience the message through a head-mounted VR device in an immersive virtual environment while watching the same video content.
2. Speaker identity
Among participants assigned to the information treatment (Video or VR), the message is delivered by speakers whose identity varies along two dimensions: professional identity (scientist vs influencer) and gender (male vs female). Participants view a sequence of short informational segments delivered by the four speakers.
The order of appearance of the speakers and the pairing between speakers and informational segments are randomized across participants to ensure that message content is not mechanically confounded with speaker identity.
The experimental session consists of three main stages.
Pre-treatment survey
Participants complete a baseline questionnaire collecting demographic characteristics, prior beliefs about vaccines, trust in the healthcare system, attitudes toward science and public institutions, and information on their social networks.
Informational exposure
Participants are exposed to the informational content according to their assigned experimental condition (Control, Video, or VR).
Post-treatment survey
Immediately after the informational exposure, participants complete a follow-up questionnaire measuring outcomes such as trust in vaccines, trust in the healthcare system, evaluation of the speaker and the message, and willingness to discuss vaccination-related topics with others.
Measures of trust in vaccines and trust in the healthcare system are collected at three points in time: pre-treatment, immediately after the intervention, and in a follow-up survey.
For participants assigned to the VR condition, the system also records behavioral engagement measures using the eye-tracking capabilities of the VR headset, including indicators of visual attention to the speaker during the experience.
The experiment takes place in a laboratory setting. Participants receive a fixed participation payment and are entered into a lottery for Apple products. The study procedures are identical across conditions except for the experimentally manipulated communication medium and the identity of the speaker.
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Secondary Outcomes (End Points)
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Before
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After
Secondary outcomes measure mechanisms through which the intervention may affect attitudes toward vaccination, as well as additional behavioral and evaluative responses to the informational message.
The main secondary outcomes include:
Willingness to discuss vaccination
Perceived credibility and evaluation of the speaker
Engagement and visual attention during the message (VR condition)
These outcomes help identify the channels through which communication medium and speaker identity influence beliefs and attitudes toward vaccination.
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Secondary Outcomes (Explanation)
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Before
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After
Willingness to Discuss with Others (Family and Friends)
This outcome captures whether the intervention changes participants' willingness to discuss different issues with others. It is measured immediately after the intervention using 0–10 scales, where higher values indicate greater willingness to discuss the topic with others (family and friends). The post-treatment survey includes the following items:
willingness to discuss vaccines;
willingness to discuss the healthcare system;
willingness to discuss social media;
willingness to discuss artificial intelligence;
willingness to discuss politics.
The main secondary outcome in this family is willingness to discuss vaccines. The other items serve as comparison or placebo discussion topics and allow us to assess whether treatment effects are specific to vaccination or extend to other domains.
Evaluation of the Speaker and of the Message
These outcomes capture participants' overall impressions of both the messenger and the informational content. They are measured immediately after exposure using a scale from -5 to 5, where higher values indicate a more positive impression. The post-treatment survey includes the following two items:
overall impression of the speaker;
overall impression of the message.
These variables are analyzed separately and capture whether the intervention changes participants' general evaluation of the person delivering the information and of the public health message itself.
Speaker Evaluation and Credibility
These outcomes capture how participants perceive the messenger delivering the public health message. They are measured immediately after exposure using 0–10 scales, where higher values indicate a more favorable evaluation of the speaker. Participants evaluate the speaker along the following dimensions:
charismatic;
persuasive;
reliable;
knowledgeable;
nice;
attractive;
passionate.
In addition to analyzing each item separately, we will construct a Perceived Speaker Quality Index using principal component analysis (PCA). The index will correspond to the first principal component of these seven items.
Visual Attention and Engagement (VR Condition)
For participants assigned to the VR condition, the study records behavioral engagement measures using the eye-tracking capabilities of the VR headset. These measures capture visual attention and engagement during exposure to the message. In particular, we will use indicators such as:
the share of time the participant's gaze is directed toward the speaker during the VR experience;
related gaze-based engagement indicators recorded by the device.
These measures are available only for participants in the VR condition and are used to study mechanisms related to attention and immersion during the informational exposure
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