Understanding Attitudes Toward Human Enhancement Technologies

Last registered on October 13, 2025

Pre-Trial

Trial Information

General Information

Title
Understanding Attitudes Toward Human Enhancement Technologies
RCT ID
AEARCTR-0016972
Initial registration date
October 08, 2025

Initial registration date is when the trial was registered.

It corresponds to when the registration was submitted to the Registry to be reviewed for publication.

First published
October 13, 2025, 10:17 AM EDT

First published corresponds to when the trial was first made public on the Registry after being reviewed.

Locations

Region

Primary Investigator

Affiliation
Johns Hopkins University

Other Primary Investigator(s)

PI Affiliation
University of Napoli Federico II
PI Affiliation
University of Napoli Federico II
PI Affiliation
Universita Cattolica del Sacro Cuore - Milano

Additional Trial Information

Status
In development
Start date
2025-10-13
End date
2025-12-31
Secondary IDs
Prior work
This trial does not extend or rely on any prior RCTs.
Abstract
We designed an experimental survey to study people's attitudes towards human enhancement technologies. Our aim is to understand the public's perception of these technologies and how information and specific features of the technology might influence these perceptions. We will administer the survey to a representative sample of US residents. Recruitment will occur through a professional survey company, Respondi/Bilendi.
External Link(s)

Registration Citation

Citation
Immordino, Giovanni et al. 2025. "Understanding Attitudes Toward Human Enhancement Technologies." AEA RCT Registry. October 13. https://doi.org/10.1257/rct.16972-1.0
Sponsors & Partners

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Experimental Details

Interventions

Intervention(s)
We administer a randomized survey experiment on attitudes toward human enhancement technologies (HETs). After a short, standardized description of HETs, each respondent is randomly assigned to evaluate one vignette that varies along pre-specified dimensions:

Benefit domain: cosmetic, health, or productivity.

Mechanism & inheritability: genetic (non-inheritable), genetic (inheritable), or non-genetic implant/device.

Purpose: restorative (return to typical levels) or enhancing (beyond typical levels).

Risk severity (probability held constant): 1% risk of mild, temporary side effects vs. 1% risk of severe, long-lasting side effects.

Distribution of productivity gains (subset of non-genetic productivity vignettes): general; complementary to college-educated work; complementary to high-school-or-less work.

Two additional randomized elements affect information salience: (i) an expectations module (shown to 50% before the vignette) and (ii) the ethics module placement (before vs. after main outcomes). The survey concludes with socio-demographics and economic-preference measures. Fieldwork is conducted by Bilendi/Respondi.
Intervention (Hidden)
Intervention Start Date
2025-10-13
Intervention End Date
2025-10-31

Primary Outcomes

Primary Outcomes (end points)
Primary adoption outcomes

Adopt (Yes/No): whether the respondent would adopt the technology if available today.

Willingness to pay (WTP): open-ended one-time USD amount among those answering “Yes.”

Reservation benefit among non-adopters (domain-specific):

Health vignettes: minimum healthy life-years required (0–10; plus “would not adopt regardless of benefit,” analyzed as a separate indicator).

Productivity vignettes: minimum annual salary increase (%) required (0–100; plus “would not adopt regardless of benefit”).

Primary policy/ethics outcomes
4. Desired regulatory stringency (0–10 slider): 0=no regulation, 10=prohibition.
5. Overall ethical concern (0–10 slider): 0=no concern, 10=significant concern.
Primary Outcomes (explanation)
These endpoints map directly to the theoretical model: adoption/WTP capture expected net benefits; reservation benefits identify the benefit increment required to switch; regulation and ethical-concern scales capture the policy and deontological components of attitudes. Randomized vignette attributes (domain, mechanism/heritability, purpose, risk severity, distribution) provide causal identification.

Secondary Outcomes

Secondary Outcomes (end points)
Attitudinal and framing outcomes
- Expectations randomization indicator: whether respondents were randomized to state expectations about societal consequences of HETs prior to the scenario (vs. not).
- Selection of specific ethical concerns (multi-select checklist: inequality, “playing God,” human nature/identity, autonomy of future generations, eugenic drift, unintended consequences, military/commercial misuse, privacy/surveillance, technological dependence, other, none).

Text-as-data outcomes
- Coded themes and sentiments from the open-ended justification (bag-of-words and dictionary/embedding methods; share mentioning specified themes).

Heterogeneity variables (not outcomes, but pre-specified moderators)

- Trust in institutions/actors; domain-specific risk tolerance; general technology orientation / early-adopter propensity; moral/morality battery; demographics (age, gender, education, income, parenthood, religion/attendance, urbanicity, health).
Secondary Outcomes (explanation)
The expectations-randomization indicator captures the priming/salience manipulation; ethical-checklist selections unpack dimensions of concern; text measures validate stated motives. We will also test whether treatment effects differ by propensity to adopt new technologies in general, alongside trust, risk attitudes, moral profiles, and demographics.

Experimental Design

Experimental Design
Overview. We run a preregistered, online survey experiment on attitudes toward human enhancement technologies (HETs). After a short standardized description of HETs, each respondent evaluates one randomly assigned vignette that varies along pre-specified dimensions. The study is fielded to a U.S. adult sample (target N≈5,000) constructed to be representative by gender, age, race/ethnicity, education, and geography, recruited by Bilendi/Respondi. A short Prolific pilot precedes fielding.

Vignette randomization. We use a factorial design that varies: (i) benefit domain (cosmetic; health; productivity), (ii) mechanism and inheritability (genetic non-inheritable; genetic inheritable; non-genetic implant/device), (iii) purpose (restorative vs. enhancing), and (iv) risk severity holding probability fixed (1% risk of mild, temporary side effects vs. 1% risk of severe, long-lasting side effects). For a subset of non-genetic productivity vignettes, we also vary the distribution of gains (general; complementary to college; complementary to high-school-or-less skills).

Additional randomized elements. Before the vignette, 50% of respondents are randomized to report expectations about societal consequences of HETs; the ethics module (global ethical-concern slider and checklist) is randomized to appear either before or after the main outcomes to test priming.
Experimental Design Details
Randomization Method
Randomization is implemented in Qualtrics. We use Qualtrics’ built-in Randomizer at the respondent level to assign treatments with equal probability. Independent randomization modules assign: (i) the vignette cell (benefit domain × mechanism/heritability × purpose × risk severity), (ii) the expectations prompt (shown before the vignette vs. not), and (iii) the placement of the ethics module (before vs. after outcomes). Randomization is executed by Qualtrics’ server-side RNG upon page load; assignment flags are stored in embedded data. Sampling quotas for representativeness (gender, age, race/ethnicity, education, geography) are handled by the panel provider and are separate from treatment assignment.
Randomization Unit
Individual
Was the treatment clustered?
No

Experiment Characteristics

Sample size: planned number of clusters
5,000 respondents
Sample size: planned number of observations
5,000
Sample size (or number of clusters) by treatment arms
Planned equal allocation via Qualtrics.

Randomization assigns respondents equally across 40 vignette cells:
- Cosmetic: 3 mechanisms (genetic non-inheritable / genetic inheritable / non-genetic) × 2 purposes (restorative / enhancing) × 2 risks (1% mild / 1% severe) = 12 cells.
- Health: same structure = 12 cells.
- Productivity: Genetic non-inheritable (restorative/enhancing) × 2 risks = 4 cells. Genetic inheritable (restorative/enhancing) × 2 risks = 4 cells. Non-genetic “general” (restorative/enhancing) × 2 risks = 4 cells. Non-genetic education-specific, enhancing only (college-complementary; HS-or-less–complementary) × 2 risks = 4 cells. Total productivity = 16 cells.

Target sample: N ≈ 5,000 U.S. adults, yielding ≈125 respondents per vignette arm (5,000 / 40).

Orthogonal cross-randomizations:
- Expectations asked pre-vignette vs. not: ~2,500 vs. ~2,500.
- Ethics module before vs. after outcomes: ~2,500 vs. ~2,500.

Final realized counts will be reported ex post.
Minimum detectable effect size for main outcomes (accounting for sample design and clustering)
IRB

Institutional Review Boards (IRBs)

IRB Name
Johns Hopkins University Homewood IRB
IRB Approval Date
2025-09-30
IRB Approval Number
HIRB00019474
IRB Name
Comitato Etico Universita degli Studi di Napoli Federico II
IRB Approval Date
2024-10-03
IRB Approval Number
N/A
Analysis Plan

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Post-Trial

Post Trial Information

Study Withdrawal

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Intervention

Is the intervention completed?
No
Data Collection Complete
Data Publication

Data Publication

Is public data available?
No

Program Files

Program Files
Reports, Papers & Other Materials

Relevant Paper(s)

Reports & Other Materials