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IMPACT EVALUATION OF ANIONIC MINERAL MIXTURE SUPPLEMENTATION ON MILK PRODUCTION AND THE MILK FEVER: A RANDOMIZED CONTROL TRIAL
Last registered on April 17, 2021

Pre-Trial

Trial Information
General Information
Title
IMPACT EVALUATION OF ANIONIC MINERAL MIXTURE SUPPLEMENTATION ON MILK PRODUCTION AND THE MILK FEVER: A RANDOMIZED CONTROL TRIAL
RCT ID
AEARCTR-0005108
Initial registration date
November 23, 2019
Last updated
April 17, 2021 12:04 AM EDT
Location(s)
Region
Primary Investigator
Affiliation
ICAR-NATIONAL DAIRY RESEARCH INSTITUTE, INDIA
Other Primary Investigator(s)
PI Affiliation
ICAR-NDRI
PI Affiliation
ICAR-IIWBR
PI Affiliation
ICAR-NDRI
PI Affiliation
ICAR-NDRI
PI Affiliation
ICAR-NDRI
PI Affiliation
ICAR-NDRI
Additional Trial Information
Status
Completed
Start date
2020-09-01
End date
2021-03-31
Secondary IDs
Abstract
Upon parturition or calving, due to increased milk production in dairy cows and buffaloes, calcium (Ca) requirement will be 10 times more than the dry period. If this requirement is not fulfilled, Ca deficiency leads to a condition called parturient hypocalcaemia or milk fever. It is an economically important disease; in Tamil Nadu alone the economic loss was estimated at ₹ 40.62 crores (Thirunavukkarasu, et al., 2010). Milk fever incidence in the field ranges from 5 - 25 per cent and in extreme cases may reach upto 80 per cent which results in huge losses to the dairy farmers (DeGaris & Lean, 2009). Supplementing negatively charged (anionic) ration before 3 weeks of calving reduces the incidence of milk fever and other diseases by increasing Ca resorption from the bones (Mani, 2018). With this background the proposed study evaluates the effectiveness of a technology commercialized by ICAR-NDRI namely ‘Anionic Mineral Mixture for reducing post-partum problems in cows and buffaloes’ using Randomized Control Trial (RCT) in the five adopted villages of NDRI.
Objectives
1. To evaluate the impact of anionic mineral mixture supplementation on milk production, incidence of milk fever and farmers’ income
2. To estimate the price sensitivity (demand elasticity) of the technology
3. To estimate the cost effectiveness and forecast the overall economic benefit of Anionic Mineral Mixture supplementation

External Link(s)
Registration Citation
Citation
Cariappa, A G Adeeth et al. 2021. "IMPACT EVALUATION OF ANIONIC MINERAL MIXTURE SUPPLEMENTATION ON MILK PRODUCTION AND THE MILK FEVER: A RANDOMIZED CONTROL TRIAL." AEA RCT Registry. April 17. https://doi.org/10.1257/rct.5108-2.0.
Sponsors & Partners
Sponsor(s)
Experimental Details
Interventions
Intervention(s)
1. Supplementing dairy farmers with anionic mineral mixture
Intervention Start Date
2020-10-01
Intervention End Date
2021-02-01
Primary Outcomes
Primary Outcomes (end points)
1. Milk production
2. Incidence of milk fever (parturient hypocalcaemia)
3. Income from dairying
Primary Outcomes (explanation)
1. Milk production is the average daily milk yield per animal. For the overall sample (cows+buffaloes), daily average fat-corrected milk yield is used.
2. Incidence of milk fever is a dummy variable taking value 1 for observed milk fever and 0 otherwise.
Secondary Outcomes
Secondary Outcomes (end points)
Income from dairying
Secondary Outcomes (explanation)
It is the value of milk produced per animal in a lactation.
Experimental Design
Experimental Design
Individual level randomization of 200 dairy farmers who own at least one pregnant bovine (cows and buffaloes) and doesn't use any other type of anionic feed. The intervention will be randomly phased in.
Experimental Design Details
Randomization Method
Randomization done in office by a computer
Randomization Unit
Individual level
Was the treatment clustered?
No
Experiment Characteristics
Sample size: planned number of clusters
200 dairy animals
Sample size: planned number of observations
200 animals
Sample size (or number of clusters) by treatment arms
100 animals in control
50 cows will be fed anionic mineral mixture
50 buffaloes receive anionic mineral mixture
Minimum detectable effect size for main outcomes (accounting for sample design and clustering)
Standardized effect size - 0.34 litres/day
IRB
INSTITUTIONAL REVIEW BOARDS (IRBs)
IRB Name
IRB Approval Date
IRB Approval Number
Post-Trial
Post Trial Information
Study Withdrawal
Intervention
Is the intervention completed?
Yes
Intervention Completion Date
February 01, 2021, 12:00 AM +00:00
Is data collection complete?
Yes
Data Collection Completion Date
March 31, 2021, 12:00 AM +00:00
Final Sample Size: Number of Clusters (Unit of Randomization)
200 dairy animals (100 cows and 100 buffaloes)
Was attrition correlated with treatment status?
No
Final Sample Size: Total Number of Observations
200 dairy animals (100 cows and 100 buffaloes)
Final Sample Size (or Number of Clusters) by Treatment Arms
50 cows fed anionic mineral mixture, 50 buffaloes fed anionic mineral mixture, 50 control cows, 50 control buffaloes. Overall - 100 treated animals, 100 control animals.
Data Publication
Data Publication
Is public data available?
No
Program Files
Program Files
Reports, Papers & Other Materials
Relevant Paper(s)
REPORTS & OTHER MATERIALS