Increasing Cancer Screening Rates and Vaccine Uptake using Digital Messages based on Insights from Behavioral Economics

Last registered on November 14, 2023

Pre-Trial

Trial Information

General Information

Title
Increasing Cancer Screening Rates and Vaccine Uptake using Digital Messages based on Insights from Behavioral Economics
RCT ID
AEARCTR-0006317
Initial registration date
September 05, 2020

Initial registration date is when the trial was registered.

It corresponds to when the registration was submitted to the Registry to be reviewed for publication.

First published
September 08, 2020, 9:35 AM EDT

First published corresponds to when the trial was first made public on the Registry after being reviewed.

Last updated
November 14, 2023, 6:44 AM EST

Last updated is the most recent time when changes to the trial's registration were published.

Locations

Primary Investigator

Affiliation
University of Haifa

Other Primary Investigator(s)

PI Affiliation
Maccabi Healthcare Services
PI Affiliation
Sarid Research Institute
PI Affiliation
Maccabi Healthcare Services
PI Affiliation
Maccabi Healthcare Services
PI Affiliation
Maccabi Healthcare Services

Additional Trial Information

Status
Completed
Start date
2020-07-29
End date
2021-12-06
Secondary IDs
Prior work
This trial does not extend or rely on any prior RCTs.
Abstract
We examine whether different types of frames increase individuals' compliance with cancer screening and vaccination. Making use of a large digital message customer journey held in Israel by Maccabi Healthcare Services, we design 5 treatments that differ in their theme and underlying appeal. The five treatments include: Positive framing (benefits of early detection), negative framing (risks of late detection), empowerment ("your health is in your own hands"), recommendation by physicians, and implementation intention. A control group receives a message that only describes the importance of the screening/vaccination and the fact that they are recommended by the ministry of health. The population includes adults between the ages of 50-74 and the targeted screenings and vaccinations are: Occult blood test, mammography, screening for early detection of abdominal aortic aneurysm, HPV and Pneumococcal vaccine.
External Link(s)

Registration Citation

Citation
Alcalay, Tamar et al. 2023. "Increasing Cancer Screening Rates and Vaccine Uptake using Digital Messages based on Insights from Behavioral Economics." AEA RCT Registry. November 14. https://doi.org/10.1257/rct.6317-3.0
Sponsors & Partners

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Experimental Details

Interventions

Intervention(s)
We have five treatments which may be considered as our interventions. Individuals insured by the HMO (Maccabi Healthcare Services) will be randomly assigned to one of 5 treatments and control. The treatments differ in the content included in the message. Each message emphasizes a different theme that is expected to increase compliance rates, based on previous behavioral and psychological research. The different treatments are: (1) Positive framing: stating the fact that early detection of a disease increases the treatment options and the chances of full recovery. (2) Negative framing: stating the fact that late detection of a disease reduces the treatment options and the chances of full recovery. (3) Empowerment: emphasizing the personal responsibility of the individual for his/her health. (4) Physician Recommendation: mentioning that doctors within the HMO recommend performing the suggested screenings. (5) Implementation Intention: presenting the screening and potential outcomes as an "if-then plan".
Intervention (Hidden)
In all treatments and control, each reach-out to an insured individual consists of three messages - all framed along the lines of the treatment she/he has been randomly assigned to. The second and third message are sent out 2 and 4 weeks after the first, respectively, only in the case that the individual did not yet schedule an appointment for one of her/his recommended screenings/vaccination. There are minor changes between the 3 messages as they are designed to be reminders that are not too repetitive. Messages are sent out by email but in cases in which this is not possible they will be sent out as text messages. Those who did not open the first message received by mail, receive it again as a reminder two days later.

The customer journey started on July 29th, 2020. The research has been approved by the research committee of Maccabi Healthcare Services and is scheduled to go through Helsinki committee and obtain approval for sharing the data for research purposes. The intervention in itself does not require informed consent, as it is part of the routine digital activities of the HMO. The data is currently in collection and is expected to be ready roughly by November 2020. The HMO plans to continue these digital customer journey campaigns continuously. Our plan in this research is to focus on the first campaign but, with agreement of the HMO, we may continue to study the following campaigns as well.

Data analysis: We plan to examine compliance rates (actual performance of screening/vaccinations) and intentions (scheduling an appointment) for each screening/vaccination and overall for each treatment and compare them to the control group. We will examine these variables in different time frames measured from the date of the last message. Our control variables will include demographics provided by Maccabi Healthcare Services. We will make use of different descriptive statistics as well as logit regression models. Other appropriate tools to analyze the data may be used as the data becomes available and the analysis begins.
Intervention Start Date
2020-07-29
Intervention End Date
2021-12-06

Primary Outcomes

Primary Outcomes (end points)
A dummy variable recording whether the individual performed the screening/got the vaccination within 2-3 months since receiving the message.
Primary Outcomes (explanation)

Secondary Outcomes

Secondary Outcomes (end points)
A dummy variable recording whether the individual scheduled an appointment to her/his recommended screening.
Secondary Outcomes (explanation)

Experimental Design

Experimental Design
The design is straightforward. 5 treatments plus a control. Treatments differ in the framing and content of the message and we will examine which of the above approaches has the highest success in increasing compliance rates.
Experimental Design Details
Randomization Method
Randomization by a computer.
Randomization Unit
Individual.
Was the treatment clustered?
No

Experiment Characteristics

Sample size: planned number of clusters
Roughly 150,000 individuals
Sample size: planned number of observations
Roughly 150,000
Sample size (or number of clusters) by treatment arms
25,000 individuals in each treatment/control
Minimum detectable effect size for main outcomes (accounting for sample design and clustering)
Assuming n=25000 in each group, significance level 0.05, power of 95%, in a two sided test, the minimum detectable effect size is h=0.032.
IRB

Institutional Review Boards (IRBs)

IRB Name
Maccabi Health Services
IRB Approval Date
2020-08-06
IRB Approval Number
Internal IRB prior to Helsinki Committee

Post-Trial

Post Trial Information

Study Withdrawal

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Intervention

Is the intervention completed?
Yes
Intervention Completion Date
December 06, 2021, 12:00 +00:00
Data Collection Complete
Yes
Data Collection Completion Date
December 06, 2021, 12:00 +00:00
Final Sample Size: Number of Clusters (Unit of Randomization)
Was attrition correlated with treatment status?
No
Final Sample Size: Total Number of Observations
129,070
Final Sample Size (or Number of Clusters) by Treatment Arms
After initial data cleaning: Control-20946, Gains-20385, Losses-15154, Recommendation-20573, Implementation Intentions-20687, Empowerment-15237
Data Publication

Data Publication

Is public data available?
No

Program Files

Program Files
Yes
Reports, Papers & Other Materials

Relevant Paper(s)

Reports & Other Materials