AEA RCT Registry

Field	Before	After
Last Published	October 21, 2020 08:36 AM	February 05, 2021 12:25 PM
Primary Outcomes (End Points)	1. Checking the PMP during the 60 days after letters were sent 2. Avoid writing any co-prescriptions during the 60 days after letters were sent	1. Number of patients with co-prescriptions during the 60 days after letters were sent 2. Indicator for checking the PMP during the 60 days after letters were sent
Power calculation: Minimum Detectable Effect Size for Main Outcomes	Binary outcomes, all treatment arms vs. control: 2.9 percentage points (assuming no power gain from stratification and statistical controls), 1.5 percentage points (assuming 75% reduction in variance from stratification and statistical controls) Binary outcomes, arm vs. arm: 3.6 percentage points (no power gain), 1.8 percentage points (75% reduction in variance)	Primary outcome 1 (number of patients with co-prescriptions) - MDE, arm-to-arm comparison: 0.19 patients (4.5% of mean) - MDE, all interventional arms vs. control: 0.15 patients (3.7% of mean) Primary outcome 2 (indicator for checking the PMP) - MDE, arm-to-arm comparison: 2.2 percentage points (4.6% of mean) - MDE, all interventional arms vs. control: 1.8 percentage points (3.7% of mean)

Fields Changed