Minimum detectable effect size for main outcomes (accounting for sample
design and clustering)
For child-level primary outcomes presented in terms of control group standard deviations, and assuming 80% power, 95% confidence, two-tailed tests, and no covariate adjustment, the MDES values for a test of treatment (pooling all variations) versus control are as follows:
ICC 0.0, MDES 0.084
ICC 0.1, MDES 0.177
ICC 0.3, MDES 0.282
ICC 0.7, MDES 0.419