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Field
Trial End Date
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Before
February 11, 2022
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After
May 01, 2022
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Field
Last Published
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Before
January 28, 2022 11:01 AM
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After
February 16, 2022 03:15 PM
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Field
Intervention End Date
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Before
February 11, 2022
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After
March 01, 2022
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Field
Planned Number of Clusters
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Before
4000 subjects
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After
4000 subjects
(Update for February 16th): 3000 additional subjects who have not previously participated.
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Field
Planned Number of Observations
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Before
4000 subjects in the main survey + 4000 subjects in a follow-up survey. All 4000 will be included in a follow-up survey, but we anticipate some attrition, so the total number of observations will likely be short of 8000.
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After
4000 subjects in the initial main survey + 4000 subjects in a follow-up to the initial survey. All 4000 will be included in a follow-up survey, but we anticipate some attrition, so the total number of observations will likely be short of 8000.
(Update for February 16th): We will be conducting an additional survey to better identify effects of certain interventions. This will involve an additional 3000 subjects who have not previously participated.
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Field
Sample size (or number of clusters) by treatment arms
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Before
Video Treatments:
1. Video Control Condition (VC )(N ≈ 1333):
2. Video Optional Condition (V1)(N ≈ 1333):
3. Video Required Condition (V2)(N ≈ 1333):
Paradox treatments:
1. Paradox Control Condition (PC )(N ≈ 1000):
2. Live Virus Paradox (PLV )(N ≈ 1000):
3. Long-Run Paradox (PLR)(N ≈ 1000):
4. Both Paradoxes (PB)(N ≈ 1000):
So, each cross-randomization cell should have a sample of approximately 333 subjects.
Motivated reasoning randomization:
1. GENERAL (N ≈ 1333)
2. MYOCARDITIS (N ≈ 1333)
3. THROMBOSIS (N ≈ 1333)
So, the full 3X4X3 factorial design should have approximately 111 subjects in each cell. However, the even cross-randomization will allow us to identify average treatment effects for each treatment without being restricted to such small samples.
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After
Video Treatments:
1. Video Control Condition (VC )(N ≈ 1333):
2. Video Optional Condition (V1)(N ≈ 1333):
3. Video Required Condition (V2)(N ≈ 1333):
Paradox treatments:
1. Paradox Control Condition (PC )(N ≈ 1000):
2. Live Virus Paradox (PLV )(N ≈ 1000):
3. Long-Run Paradox (PLR)(N ≈ 1000):
4. Both Paradoxes (PB)(N ≈ 1000):
So, each cross-randomization cell should have a sample of approximately 333 subjects.
Motivated reasoning randomization:
1. GENERAL (N ≈ 1333)
2. MYOCARDITIS (N ≈ 1333)
3. THROMBOSIS (N ≈ 1333)
So, the full 3X4X3 factorial design should have approximately 111 subjects in each cell. However, the even cross-randomization will allow us to identify average treatment effects for each treatment without being restricted to such small samples.
(Update for February 16th): In our additional survey, we will simplify the design to better understand the additivity of interventions. These 3000 additional subjects will be assigned using a 2x2 randomization.
Paradox treatment random assignment:
1. Paradox Control Condition (PC ) (N ≈ 1500)
2. Both Paradoxes (PB) (N ≈ 1500)
Video treatment independent random assignment:
1. Video Control Condition (VC ) (N ≈ 1500)
2. Video Required (VR) (N ≈ 1500)
Thus, each cell of the 2X2 for the additional study will contain approximately 750 subjects.
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