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Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study

Last registered on January 02, 2024

Pre-Trial

Trial Information

General Information

Title
Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study
RCT ID
AEARCTR-0012767
Initial registration date
December 31, 2023

Initial registration date is when the trial was registered.

It corresponds to when the registration was submitted to the Registry to be reviewed for publication.

First published
January 02, 2024, 11:02 AM EST

First published corresponds to when the trial was first made public on the Registry after being reviewed.

Locations

Region

Primary Investigator

Affiliation
Foundation University Islamabad

Other Primary Investigator(s)

PI Affiliation
Foundation University Islamabad
PI Affiliation
Foundation University Islamabad
PI Affiliation
Foundation University Islamabad

Additional Trial Information

Status
On going
Start date
2023-07-01
End date
2024-01-15
Secondary IDs
Prior work
This trial does not extend or rely on any prior RCTs.
Abstract
Vivid perceptions of nonexistent events are produced by hallucinations, which can appear in a variety of sensory modalities and occur in the absence of sensory stimuli. The notion that associative learning experiences can elicit conditioning-induced hallucinations has been effectively utilized by methods from the fields of experimental and cognitive psychology. In this work, we expand on the existing literature by emphasizing how induced hallucinations can heighten users' cognitive experiences, along with focusing on the physical and psychological effects of using it. In order to determine users' cognitive functioning when exposed to induced hallucinations, we first carried out a preliminary experiment without audio conditioning. The findings indicated that specific circumstances may affect the memory of the individual. After that, we created an interactive scenario aimed at inducing mild to moderate positive visual hallucinations conditioned with negative audio and negative visual hallucinations conditioned with positive audio and then with combining positive auditory-visual hallucinations and negative auditory-visual hallucinations. Participants acted out the scenario in visually induced hallucinations and also in visually induced hallucinations conditioned with the audio. Participants who practiced the hallucinations conditioned with audio reported higher levels of absorption, which subsequently raised the intensity of their cognitive response to the event. The individuals' cognitive states were assessed using a Semantic memory scale and PANSS to assess positive and negative symptoms using advance software Psychopy. After being exposed to conditionally evoked hallucinations; the individuals' cognitive functioning was disturbed.
External Link(s)

Registration Citation

Citation
Aqeel, Dr. Muhammad et al. 2024. "Effect of Audio-Visio Hallucinations on Memory in healthy individuals: an Experimental Study." AEA RCT Registry. January 02. https://doi.org/10.1257/rct.12767-1.0
Experimental Details

Interventions

Intervention(s)
To explore effect of conditioning evoked hallucinations on memory of healthy individuals
Intervention (Hidden)
To explore effect of conditioning evoked hallucinations on memory of healthy individuals
Intervention Start Date
2023-07-01
Intervention End Date
2024-01-15

Primary Outcomes

Primary Outcomes (end points)
The significance of this experimental study is embedded in its research design. We are using a completely different approach to assess cognitive change. The cross-sectional designs, while potentially well-suited for large samples, are often underpowered, overgeneralized, and ill-approximated to the statistical assumptions implied by general linear methods. For these reasons, we are experimenting with time-series techniques to explicitly investigate the time-dependent variation that can be observed within individual subjects. We are going to assess cognitive changes of induced hallucinations both visual and auditory with different pairings between them over a very short period of time. We are going to find a direct relationship of hallucinations on the cognitive functioning especially on memory of human beings. This study will increase people’s interests towards temporal and time-series studies.
Primary Outcomes (explanation)
to develop interest in research

Secondary Outcomes

Secondary Outcomes (end points)
To develop interest in Research by promoting Experimental studies
Secondary Outcomes (explanation)
To develop interest in Research by promoting Experimental studies

Experimental Design

Experimental Design
This study was a temporal, double blinded, 2*factorial design, Randomized Controlled Trial and Block Design experiment conducting using Psychopy. At first, memory was assessed using Semantic memory scale along with PANNS scale to measure Positive and Negative symptoms after giving each stimuli i.e; showing positive video, negative video, positive audio, negative video at T0, Then Positive Visual hallucination conditioned with positive audio was induced and assessment again take place at last at T1. In the T2 phase, Positive visual hallucinations conditioned with the negative audio were induced and cognition was assessed. In the T3 phase, negative visual hallucinations conditioned with negative audio were induced to assess the cognitive functioning. In the last stage T4, Negative hallucinations conditioned with positive audio were induced to assess the cognitive functioning of the participants.
Experimental Design Details
This study was a temporal, double blinded, 2*factorial design, Randomized Controlled Trial and Block Design experiment conducting using Psychopy. At first, memory was assessed using Semantic memory scale along with PANNS scale to measure Positive and Negative symptoms after giving each stimuli i.e; showing positive video, negative video, positive audio, negative video at T0, Then Positive Visual hallucination conditioned with positive audio was induced and assessment again take place at last at T1. In the T2 phase, Positive visual hallucinations conditioned with the negative audio were induced and cognition was assessed. In the T3 phase, negative visual hallucinations conditioned with negative audio were induced to assess the cognitive functioning. In the last stage T4, Negative hallucinations conditioned with positive audio were induced to assess the cognitive functioning of the participants.
Randomization Method
Randomized done using PsychoPy.
Randomization Unit
40 individuals
Was the treatment clustered?
No

Experiment Characteristics

Sample size: planned number of clusters
40 university students
Sample size: planned number of observations
40
Sample size (or number of clusters) by treatment arms
40 students for experiment
Minimum detectable effect size for main outcomes (accounting for sample design and clustering)
Supporting Documents and Materials

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IRB

Institutional Review Boards (IRBs)

IRB Name
IRB Approval Date
IRB Approval Number

Post-Trial

Post Trial Information

Study Withdrawal

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Intervention

Is the intervention completed?
No
Data Collection Complete
Data Publication

Data Publication

Is public data available?
No

Program Files

Program Files
Reports, Papers & Other Materials

Relevant Paper(s)

Reports & Other Materials