Baby's First Years

We are randomly assigning 1,000 US low-income mothers and their newborns in four ethnically and geographically diverse metropolitan areas to either (1) an experimental group that receives $333 in cash payments each month ($4,000 each year) for each of the first 40 months of the children’s lives, with the first payments occurring shortly after the baby’s birth and this experimental condition offered to 40% of the participants, or (2) an active comparator group that receives much smaller payments ($20 per month) offered to 60% of participants. Based on our and others’ prior work, the $3,760 annual difference will be large enough to produce and detect meaningful differences in children’s cognitive development.

Moreover, to understand how poverty reduction improves brain functioning, we have three follow-up waves of data collection conducted at child ages 12, 24 and 36 months. Cognitive and emotional development measures will be gathered at 12, 24, and 36 months of age. At the age-three lab visit we will administer validated, reliable and developmentally sensitive measures of language, memory, executive functioning and socioemotional skills. We will also collect direct measures of young children’s brain development at ages 1 and 3.

The family process measures that we will gather are based on two theories of change surrounding the income supplements: that increased investment and reduced stress will facilitate children’s healthy development. We will obtain data measuring both of these pathways annually. Investment pathway: Additional resources enable parents to buy goods and services for their families and children that support cognitive development. These include higher quality housing, nutrition and non-parental child care; more cognitively stimulating home environments and learning opportunities outside of the home; and, by reducing or restructuring work hours, more parental time spent with children. Stress pathway: A second pathway is that additional economic resources may reduce parents’ own stress and improve their mental health. This may allow parents to devote more positive attention to their children, thus providing a more predictable family life, less conflicted relationships, and warmer and more responsive interactions.

We have worked with state and local officials to ensure to the extent feasible that our cash gifts are not considered countable income for the purposes of determining benefit levels from social assistance programs.

2018-05-09

2022-06-01

1. Child Language Development at age 36 months
2. Child Executive Function and Self-Regulation at age 36 months
3. Child Socio-emotional Processing at age 36 months
4. Child IQ at age 36 months
5. Child Brain Function at age 36 months
6. Child Sleep at age 36 months
7. Child Body Mass Index at age 36 months
8. Child Health at 36 months
9. Child's School Achievement starting at age 6 years
10. Maternal Physiological Stress at age 36 months
11. Parent-Child Interaction Quality at age 24 months

Here we list primary outcome measures. Details can be found in Appendix Tables 3 and 4 of the "Analysis Plan and Measures" document .

1. Child Language Development at age 36 months: Language Processing measured using the Quick Interactive Language Screener- Language Processing Subscale (QUILS) (subject to change following pilot testing; we will estimate the statistical significance of the entire family of related measures in the Child Language Development outcome cluster using stepdown resampling methods for multiple testing)

2. Child Executive Function and Self-Regulation at age 36 months: Executive Function measured using one of the following (to be determined following pilot testing): Minnesota Executive Function Scale, EF Touch Executive Functioning, or Wechsler preschool and primary scale of intelligence—fourth edition- Working Memory Scale (WPPSI-IV) and Self-Regulation measured using Preschool Self-Regulation Assessment (we will estimate the statistical significance of the entire family of related measures in the Child Executive Function and Self-Regulation outcome cluster using stepdown resampling methods for multiple testing)

3. Child Socio-emotional Processing at age 36 months: Social-Emotional Problems measured using the Brief Infant-Toddler Social and Emotional Assessment (BITSEA) and Behavior/Emotional Problems measured using the Child Behavior Checklist (we will estimate the statistical significance of the entire family of related measures in the Child Socioemotional Processing outcome cluster using stepdown resampling methods for multiple testing)

4. Child IQ at age 36 months measured using the Wechsler preschool and primary scale of intelligence—fourth edition (WPPSI-IV)

5. Child Brain Function at age 36 months: Resting brain function measuring Gamma, Alpha and Theta power using EEG resting high-frequency power (waves adjusted for multiple testing bias) (we will estimate the statistical significance of the entire family of related measures in the Child Brain Function outcome cluster using stepdown resampling methods for multiple testing)

6. Child Sleep at age 36 months using the Patient-Reported Outcomes Measurement Information System (PROMIS™) Sleep Disturbance (SD) Short Form

7. Child Body Mass Index at age 36 months measured using CDC scales

8. Child Health at 36 months measured using an additive index of six survey items (see Appendix Table 3 in the document titled "Analysis Plan and Outcome Measures" for items)

9. Child's School Achievement starting at age 6 measured using administrative test score data

10. Maternal Physiological Stress at age 36 months measured using maternal hair cortisol

11. Parent-Child Interaction Quality at age 24 months measured: Index of mother's positive parenting behaviors measured using the Parenting Interactions with Children: Checklist of Observations Linked to Outcomes (PICCOLO™) to code NICHD SECCYD Mother-Child Interaction Task (adapted script) (we will estimate the statistical significance of the entire family of related measures in the Parent-Child Interaction Quality outcome cluster using stepdown resampling methods for multiple testing)

1. Child Language Development at ages 12, 24, 36 months
2. Child Socioemotional Processing at ages 12, 24 months
3. Child Brain Function at ages 12 and 36 months
4. Child Physiological Stress at age 36 months
5. Child Sleep at ages 12, 24 months
6. Child Health at ages 12, 24 months
7. Child Epigenetic Age at age 24 months
8. Child DNA Methylation at age 24 months
9. Child's Siblings' School Achievement starting at age 6 years
10. Child and Sibling School Behavior starting at age 6 years
11. Child Nutrition at age 24 months
12. Household Economic Hardship at ages 12, 24, 36 months
13. Social Services Receipt at ages 12, 24, 36 months
14. Mother's Labor Market and Education Participation at ages 12, 24, 36 months
15. Child-Focused Expenditures at ages 12, 24, 36 months
16. Housing and Neighborhood Quality at ages 12, 24, 36 months
17. Family and Maternal Perceived Stress at ages 12, 24, 36 months
18. Maternal Happiness and Optimism at ages 12, 24, 36 months
19. Maternal Physiological Stress at age 12 months
20. Maternal Mental Resources at age 24 months
21. Maternal Mental Health at ages 12, 24, 36 months
22. Maternal Physical Health at ages 12, 24, 36 months
23. Maternal Substance Abuse at ages 12 and 36 months
24. Chaos in the Home at ages 12, 24, 36 months
25. Maternal Relationships at ages 12, 24, 36 months
26. Parent-Child Interaction Quality at ages 12, 24 months
27. Maternal Epigenetic Age at age 24 months
28. Maternal DNA Methylation at age 24 months
29. Frequency of Parent-Child Activity at ages 12 and 24 months
30. Maternal Discipline at ages 12 and 24 months

Here we list secondary outcome measures. Details can be found in Appendix Tables 3 and 4 of the document "Analysis Plan and Measures".

1. Child Language Development at ages 12, 24, 36 months: Language Milestones measured using Ages and Stages Questionnaire (ASQ)- Communication Subscale (at ages 12 and 36 months); Child Vocalizations measured using LENA Technology software (at age 24 months); Communicative Development measured using the short-form versions of the MacArthur Communicative Development Inventories (at age 24 months); Verbal Comprehension measured using the Wechsler Preschool and Primary Scale of Intelligence-fourth edition (WPPSI-IV)- Vocabulary Subscale (at age 36 months); (we will estimate the statistical significance of the entire family of related measures in the Child Language Development outcome cluster using stepdown resampling methods for multiple testing)

2. Child Socioemotional Processing at ages 12 and 24 months: Social-Emotional Problems measured using the Brief Infant-Toddler Social and Emotional Assessment (BITSEA); Social-Emotional Behavior measured using the NICHD SECCYD Mother-Child Interaction Task (positive/negative mood, activity level, sustained attention, positive engagement); (we will estimate the statistical significance of the entire family of related measures in the Child Socioemotional Processing outcome cluster using stepdown resampling methods for multiple testing)

3. Child Brain Function at ages 12 and 36 months: Resting brain function measuring Gamma, Alpha and Theta power using EEG resting high-frequency power (waves adjusted for multiple testing bias) (at age 12 months); Language-related brain function measuring Alpha, Gamma and Theta power using EEG (waves adjusted for multiple testing bias) (at age 36 months); (we will estimate the statistical significance of the entire family of related measures in the Child Brain Function outcome cluster using stepdown resampling methods for multiple testing)

4. Child Physiological Stress at age 36 months measured using child's Hair cortisol

5. Child Sleep at ages 12 and 24 months measured using the Patient-Reported Outcomes Measurement Information System (PROMIS™) Sleep Disturbance (SD) Short Form

6. Child Health at ages 12 and 24 months measured using an index of survey items (see Appendix Table 3 in the document titled "Analysis Plan and Outcome Measures" for items)

7. Child Epigenetic Age at age 24 months: Measured using the method following Fiorito et al. (2017) (see the Bibliography of Child Focused Pre-registered Hypotheses in in the document titled "Analysis Plan and Outcome Measures" for the full citation)

8. Child DNA Methylation at age 24 months: Measured using the method following Hughes et al. (2018) and Cao-Lei et al. (2014) (see the Bibliography of Child Focused Pre-registered Hypotheses in in the document titled "Analysis Plan and Outcome Measures" for the full citation)

9. Child's Siblings' School Achievement starting at age 6 years using administrative test score data

10. Child and Sibling School Behavior starting at age 6 years using administrative data

11. Child Nutrition at age 24 months: Consumption of healthy foods measured using an additive index of survey items; Consumption of unhealthy foods measured using an additive index of survey items; (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items)

12. Household Economic Hardship at ages 12, 24, 36 months: Index of food insufficiency measured using the U.S. Household Food Security Survey Module: Six-Item Short Form; Index of economic stress using an additive index of survey items, with higher score indicating higher stress (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items); Household Poverty measured using Census Bureau's thresholds; (we will estimate the statistical significance of the entire family of related measures in the Household Economic Stress outcome cluster using stepdown resampling methods for multiple testing)

13. Social Services Receipt at ages 12, 24, 36 months measured by the number of benefits received by mother (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items)

14. Mother's Labor Market and Education Participation at ages 12, 24, 36 months: Time to labor market reentry from birth (at age 12 months); Time to full-time labor market reentry from birth (at age 12 months); Dichotomous indicator of mother's education and training activity participation (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items); (we will estimate the statistical significance of the entire family of related measures in the Mother's Labor Market and Education Participation outcome cluster using stepdown resampling methods for multiple testing)

15. Child-Focused Expenditures at age 12, 24, 36 months: Index of child-focused expenditures since birth (at age 12 months); Total dollar amount of child-focused expenditures in the past 30 days; Cost of paid child care in dollars; Dichotomous indicator of use of center-based care (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items); (we will estimate the statistical significance of the entire family of related measures in the Child-Focused Expenditures outcome cluster using stepdown resampling methods for multiple testing)

16. Housing and Neighborhood Quality at ages 12, 24, 36 months: Additive index of perceptions of neighborhood safety with higher score indicating feeling more safe; Additive index of housing quality; Additive index of items indicating experiences with homelessness; Excessive residential mobility measured using an indicator of three or more residential moves; Neighborhood Poverty Rate using census data (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items); (we will estimate the statistical significance of the entire family of related measures in the Housing and Neighborhood Quality outcome cluster using stepdown resampling methods for multiple testing)

17. Family and Maternal Perceived Stress at ages 12, 24, 36 months: Perceived Stress Scale (PSS); Parenting Stress measured using the Aggravation in Parenting Scale; (we will estimate the statistical significance of the entire family of related measures in the Family and Maternal Perceived Stress outcome cluster using stepdown resampling methods for multiple testing)

18. Maternal Happiness and Optimism at ages 12, 24, 36 months: Global happiness measured using a survey item (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for item); Maternal Agency measured using the HOPE Scale; (we will estimate the statistical significance of the entire family of related measures in the Family and Maternal Happiness and Optimism outcome cluster using stepdown resampling methods for multiple testing)

19. Maternal Physiological Stress at age 12 months measured using maternal hair cortisol

20. Maternal Mental Resources at age 24 months measured using the Flanker Inhibitory Control and Attention Test

21. Maternal Mental Health at ages 12, 24, 36 months: Depression measured using the PHQ-8; Anxiety measured using the Beck Anxiety Inventory (at ages 12 and 36 months); Anxiety measured using the GAD-7 (at age 24 months); (we will estimate the statistical significance of the entire family of related measures in the Maternal Mental Health outcome cluster using stepdown resampling methods for multiple testing)

22. Maternal Physical Health at ages 12, 24, 36 months: Global health measured using a survey item; Sleep measured using an additive index of survey items (at ages 12 and 36 months); Mother's Body Mass Index measured by dividing weight by stature (at age 36 months) (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items) (we will estimate the statistical significance of the entire family of related measures in the Maternal Substance Abuse outcome cluster using stepdown resampling methods for multiple testing)

23. Maternal Substance Abuse at ages 12 and 36 months: Index of frequency of alcohol and cigarette use; frequency of opioid use (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items) (we will estimate the statistical significance of the entire family of related measures in the Maternal Substance Abuse outcome cluster using stepdown resampling methods for multiple testing)

24. Chaos in the Home at ages 12, 24, 36 months: Measured using the Home Environment Chaos Scale

25. Maternal Relationship Quality at ages 12, 24, 36 months: Index of frequency of arguing; Presence of physical abuse measured using a dichotomous indicator, Index of relationship quality measured using survey items (at age 12 months); dichotomous indicator of high or low quality relationship, where 0 is defined as not in a relationship or a score above 26 on the Index of relationship quality and 1 is defined as in a relationship and a score of 26 or below on the Index of Relationship quality (at ages 24 and 36 months); (see Appendix Table 4 in the document titled "Analysis Plan and Outcome Measures" for items); (we will estimate the statistical significance of the entire family of related measures in the Maternal Relationship Quality outcome cluster using stepdown resampling methods for multiple testing)

26. Parent-Child Interaction Quality at ages 12 and 24 months: Adult word count measured using LENA Technology software; Conversational turns measured using LENA Technology software; Index of mother's positive parenting behaviors measured using the Parenting Interactions with Children: Checklist of Observations Linked to Outcomes (PICCOLO™) to code NICHD SECCYD Mother-Child Interaction Task (adapted script) (at age 12 months); (we will estimate the statistical significance of the entire family of related measures in the Parent-Child Interaction

There are two arms of interventions. The experimental group or high cash gift group (compromising 40% of all participants) receives a monthly $333 cash gift for 40 months via debit card. The comparison group or low cash gift group (compromising 60% of all participants) receives a monthly $20 cash gift for 40 months via debit card. Interviewers are aware of experimental status at enrollment in order to activate the debit card after the participant consents to the study.

Not available

Computer-randomized and computer-accessed lists of experimental and control status for participants in each for the four sites. Interviewers are notified of experimental/control data during their enrollment interviews. All of the four metropolitan sites will have a 40/60 distribution of experimental and control cases.

Individual

Yes

4 metropolitan areas

1,000 mother/infant pairs, recruited in hospitals shortly after birth. Inclusion conditions (all must be met) include: 1. mother 18 years or older 2. household income below the federal poverty threshold in the calendar year prior to the interview, counting the newborn 3. infant admitted to the newborn nursery and not requiring admittance to the intensive care unit 4. residence in the state of recruitment 5. mother reports not "highly likely" to move to a different state or country in the next 12 months 6. infant to be discharged in the custody of the mother 7. Mother English or Spanish speaking (necessary for administration of instruments used to measure some of the child outcomes)

400 in experimental group; 600 in control group. In New York City, we recruited 289 mother-infant dyads. We recruited 295 mother-infant dyads in the Omaha metropolitan area and the New Orleans metropolitan area. Lastly, we recruited 121 mother-infant dyads in the Twin Cities, MN.

.218 sd. The compensation difference between families in the experimental and control groups amounts to $313 per month and $12,520 over the course of the 40 months. This amount is in the range of income increases associated with child impacts of around .20 sd in studies of welfare experiments and the EITC. After accounting for likely 20% attrition, and in the absence of adjustments for sample clustering within hospitals or increased precision owing to the inclusion of baseline covariates in our impact estimates, the sample size of 800 at age 3, evenly divided between experimental and control groups, provides 80% statistical power to detect a .218 sd impact at p <.05 in a two-tailed test on cognitive functioning and family processes. Given the directional nature of all of our impact hypotheses, it could be argued that a one-tailed test is more appropriate, in which case our 80% power minimum detectable effect (MDE) size drops to .194 sd. The use of baseline covariates in estimation models will improve this power, while the use of bootstrap standard errors will decrease it, yielding offsetting effects of unknown but likely modest magnitudes.

Analysis Plan and Measures- Update for (and prior to) age 12 months data collection

Analysis Plan and Measures- Updated for (and prior to) age 24 months data collection